USC-OGP 2-DE database

Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database 
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Searching in 'USC-OGP 2-DE database' for entry matching: RS3_HUMAN

USC-OGP 2-DE database:  RS3_HUMAN


General information about the entry
View entry in simple text format
Entry nameRS3_HUMAN
Primary accession numberP23396
integrated into USC-OGP 2-DE database on January 17, 2017 (release 1)
2D Annotations were last modified onJanuary 17, 2017 (version 1)
General Annotations were last modified on April 5, 2017 (version 2)
Name and origin of the protein
DescriptionRecName: Full=40S ribosomal protein S3; EC= {ECO:0000269|PubMed:7775413}; AltName: Full=Small ribosomal subunit protein uS3 {ECO:0000303|PubMed:24524803};.
Gene nameName=RPS3
Annotated speciesHomo sapiens (Human) [TaxID: 9606]
TaxonomyEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein

Homo sapiens (Human)
  map experimental info

pI=5.77; Mw=31502

UniProtKB/Swiss-ProtP23396; RS3_HUMAN.

2D PAGE maps for identified proteins
  • How to interpret a protein map
  • You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
  • Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
  • Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 0.0
Entry nameRS3_HUMAN
Primary accession numberP23396
Secondary accession number(s) B2R7N5 J3KN86 Q498B5 Q8NI95
Sequence was last modified on October 1, 1993 (version 2)
Annotations were last modified on March 15, 2017 (version 195)
Name and origin of the protein
DescriptionRecName: Full=40S ribosomal protein S3; EC= {ECO:0000269|PubMed:7775413}; AltName: Full=Small ribosomal subunit protein uS3 {ECO:0000303|PubMed:24524803};
Gene nameName=RPS3
Encoded onName=RPS3; ORFNames=OK/SW-cl.26
Keywords3D-structure; Acetylation; Alternative splicing; Apoptosis; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; DNA damage; DNA repair; DNA-binding; Isopeptide bond; Lyase; Membrane; Methylation; Mitochondrion; Mitochondrion inner membrane; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; Transcription; Transcription regulation; Translation regulation; Ubl conjugation.
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License
EMBLU14990; AAB60336.1; -; mRNA
EMBLU14991; AAB60337.1; -; mRNA
EMBLU14992; AAB60338.1; -; mRNA
EMBLX55715; CAA39248.1; -; mRNA
EMBLS42658; AAB19349.2; -; mRNA
EMBLAB061838; BAB79476.1; -; Genomic_DNA
EMBLAY791291; AAV40835.1; -; Genomic_DNA
EMBLAK313051; BAG35882.1; -; mRNA
EMBLCH471076; EAW74963.1; -; Genomic_DNA
EMBLBC003137; AAH03137.1; -; mRNA
EMBLBC003577; AAH03577.1; -; mRNA
EMBLBC013196; AAH13196.1; -; mRNA
EMBLBC034149; AAH34149.1; -; mRNA
EMBLBC071917; AAH71917.1; -; mRNA
EMBLBC100284; AAI00285.1; -; mRNA
EMBLL16016; AAA18095.1; -; Genomic_DNA
EMBLAB062288; BAB93471.1; ALT_INIT; mRNA
CCDSCCDS58161.1; -. [P23396-2]; .
CCDSCCDS8236.1; -. [P23396-1]; .
PIRA41247; R3HUS3; .
RefSeqNP_000996.2; NM_001005.4. [P23396-1]; .
RefSeqNP_001243731.1; NM_001256802.1. [P23396-1]; .
RefSeqNP_001247435.1; NM_001260506.1. [P23396-2]; .
RefSeqNP_001247436.1; NM_001260507.1; .
UniGeneHs.546286; -; .
UniGeneHs.740358; -; .
PDB1WH9; NMR; -; A=17-95
PDB4UG0; EM; -; SD=1-243
PDB4V6X; EM; 5.00 A; AD=1-243
PDB5A2Q; EM; 3.90 A; D=1-243
PDB5AJ0; EM; 3.50 A; BD=1-243
PDB5FLX; EM; 3.90 A; D=1-243
PDB5T2C; EM; 3.60 A; Aq=1-243
PDBsum1WH9; -; .
PDBsum4UG0; -; .
PDBsum4V6X; -; .
PDBsum5A2Q; -; .
PDBsum5AJ0; -; .
PDBsum5FLX; -; .
PDBsum5T2C; -; .
ProteinModelPortalP23396; -; .
SMRP23396; -; .
BioGrid112102; 258; .
DIPDIP-33177N; -; .
IntActP23396; 73; .
MINTMINT-4999144; -; .
STRING9606.ENSP00000433821; -; .
iPTMnetP23396; -; .
PhosphoSitePlusP23396; -; .
SwissPalmP23396; -; .
BioMutaRPS3; -; .
DMDM417719; -; .
EPDP23396; -; .
MaxQBP23396; -; .
PaxDbP23396; -; .
PeptideAtlasP23396; -; .
PRIDEP23396; -; .
DNASU6188; -; .
EnsemblENST00000278572; ENSP00000278572; ENSG00000149273. [P23396-2]; .
EnsemblENST00000524851; ENSP00000433821; ENSG00000149273. [P23396-1]; .
EnsemblENST00000527446; ENSP00000436971; ENSG00000149273. [P23396-1]; .
EnsemblENST00000531188; ENSP00000434643; ENSG00000149273. [P23396-1]; .
GeneID6188; -; .
KEGGhsa:6188; -; .
UCSCuc001owh.5; human. [P23396-1]; .
CTD6188; -; .
DisGeNET6188; -; .
GeneCardsRPS3; -; .
HGNCHGNC:10420; RPS3; .
HPAHPA063339; -; .
MIM600454; gene; .
neXtProtNX_P23396; -; .
OpenTargetsENSG00000149273; -; .
PharmGKBPA34829; -; .
eggNOGKOG3181; Eukaryota; .
eggNOGCOG0092; LUCA; .
GeneTreeENSGT00390000008610; -; .
HOGENOMHOG000210611; -; .
HOVERGENHBG002195; -; .
InParanoidP23396; -; .
KOK02985; -; .
OrthoDBEOG091G0I8D; -; .
PhylomeDBP23396; -; .
TreeFamTF300901; -; .
ReactomeR-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression; .
ReactomeR-HSA-156902; Peptide chain elongation; .
ReactomeR-HSA-1799339; SRP-dependent cotranslational protein targeting to membrane; .
ReactomeR-HSA-192823; Viral mRNA Translation; .
ReactomeR-HSA-2408557; Selenocysteine synthesis; .
ReactomeR-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol; .
ReactomeR-HSA-72649; Translation initiation complex formation; .
ReactomeR-HSA-72689; Formation of a pool of free 40S subunits; .
ReactomeR-HSA-72695; Formation of the ternary complex; and subsequently; the 43S complex
ReactomeR-HSA-72702; Ribosomal scanning and start codon recognition; .
ReactomeR-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit; .
ReactomeR-HSA-72764; Eukaryotic Translation Termination; .
ReactomeR-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); .
ReactomeR-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); .
SIGNORP23396; -; .
ChiTaRSRPS3; human; .
EvolutionaryTraceP23396; -; .
GeneWikiRPS3; -; .
GenomeRNAi6188; -; .
PROPR:P23396; -; .
ProteomesUP000005640; Chromosome 11; .
BgeeENSG00000149273; -; .
CleanExHS_RPS3; -; .
ExpressionAtlasP23396; baseline and differential; .
GenevisibleP23396; HS; .
GOGO:0005737; C:cytoplasm; IDA:UniProtKB; .
GOGO:0005829; C:cytosol; IDA:UniProtKB; .
GOGO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB; .
GOGO:0005783; C:endoplasmic reticulum; IDA:HPA; .
GOGO:0070062; C:extracellular exosome; IDA:UniProtKB; .
GOGO:0031012; C:extracellular matrix; IDA:BHF-UCL; .
GOGO:0005925; C:focal adhesion; IDA:UniProtKB; .
GOGO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB; .
GOGO:0016020; C:membrane; IDA:UniProtKB; .
GOGO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB; .
GOGO:0005759; C:mitochondrial matrix; IDA:UniProtKB; .
GOGO:0072686; C:mitotic spindle; IDA:UniProtKB; .
GOGO:0005730; C:nucleolus; IDA:UniProtKB; .
GOGO:0005654; C:nucleoplasm; TAS:Reactome; .
GOGO:0005634; C:nucleus; IDA:UniProtKB; .
GOGO:0005886; C:plasma membrane; IDA:UniProtKB; .
GOGO:0005844; C:polysome; IDA:UniProtKB; .
GOGO:0005840; C:ribosome; IDA:UniProtKB; .
GOGO:0032587; C:ruffle membrane; IDA:UniProtKB; .
GOGO:0003684; F:damaged DNA binding; IDA:UniProtKB; .
GOGO:0003677; F:DNA binding; IDA:UniProtKB; .
GOGO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IDA:UniProtKB; .
GOGO:0004520; F:endodeoxyribonuclease activity; IDA:UniProtKB; .
GOGO:0019899; F:enzyme binding; IPI:UniProtKB; .
GOGO:0030544; F:Hsp70 protein binding; IDA:UniProtKB; .
GOGO:0051879; F:Hsp90 protein binding; IDA:UniProtKB; .
GOGO:0051536; F:iron-sulfur cluster binding; NAS:UniProtKB; .
GOGO:0019900; F:kinase binding; IPI:UniProtKB; .
GOGO:0008017; F:microtubule binding; IDA:UniProtKB; .
GOGO:0003729; F:mRNA binding; IDA:UniProtKB; .
GOGO:0032357; F:oxidized purine DNA binding; IDA:UniProtKB; .
GOGO:0032358; F:oxidized pyrimidine DNA binding; IDA:UniProtKB; .
GOGO:0051018; F:protein kinase A binding; IPI:UniProtKB; .
GOGO:0019901; F:protein kinase binding; IPI:UniProtKB; .
GOGO:0003723; F:RNA binding; IDA:UniProtKB; .
GOGO:0070181; F:small ribosomal subunit rRNA binding; IDA:UniProtKB; .
GOGO:0003735; F:structural constituent of ribosome; IDA:UniProtKB; .
GOGO:0032183; F:SUMO binding; IPI:UniProtKB; .
GOGO:0097100; F:supercoiled DNA binding; IDA:UniProtKB; .
GOGO:0008134; F:transcription factor binding; IPI:UniProtKB; .
GOGO:0015631; F:tubulin binding; IDA:UniProtKB; .
GOGO:0044390; F:ubiquitin-like protein conjugating enzyme binding; IPI:UniProtKB; .
GOGO:0006915; P:apoptotic process; IEA:UniProtKB-KW; .
GOGO:0051301; P:cell division; IEA:UniProtKB-KW; .
GOGO:0006974; P:cellular response to DNA damage stimulus; IEP:UniProtKB; .
GOGO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB; .
GOGO:0007059; P:chromosome segregation; IMP:UniProtKB; .
GOGO:0042769; P:DNA damage response; detection of DNA damage; IDA:UniProtKB
GOGO:0006281; P:DNA repair; IEA:UniProtKB-KW; .
GOGO:0007067; P:mitotic nuclear division; IEA:UniProtKB-KW; .
GOGO:0045738; P:negative regulation of DNA repair; IMP:UniProtKB; .
GOGO:0031397; P:negative regulation of protein ubiquitination; IDA:UniProtKB; .
GOGO:0017148; P:negative regulation of translation; IDA:UniProtKB; .
GOGO:0000184; P:nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; TAS:Reactome
GOGO:2001235; P:positive regulation of apoptotic signaling pathway; IDA:UniProtKB; .
GOGO:1905053; P:positive regulation of base-excision repair; IDA:UniProtKB; .
GOGO:2001272; P:positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; IMP:UniProtKB; .
GOGO:1902546; P:positive regulation of DNA N-glycosylase activity; IDA:UniProtKB; .
GOGO:0045739; P:positive regulation of DNA repair; IDA:UniProtKB; .
GOGO:0032079; P:positive regulation of endodeoxyribonuclease activity; IDA:UniProtKB; .
GOGO:0010628; P:positive regulation of gene expression; IMP:UniProtKB; .
GOGO:1902231; P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IMP:UniProtKB; .
GOGO:0043507; P:positive regulation of JUN kinase activity; IMP:UniProtKB; .
GOGO:0031116; P:positive regulation of microtubule polymerization; IMP:UniProtKB; .
GOGO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IDA:UniProtKB; .
GOGO:0042981; P:regulation of apoptotic process; IMP:UniProtKB; .
GOGO:0006355; P:regulation of transcription; DNA-templated; IEA:UniProtKB-KW
GOGO:0006979; P:response to oxidative stress; IDA:UniProtKB; .
GOGO:0061481; P:response to TNF agonist; IDA:UniProtKB; .
GOGO:0006364; P:rRNA processing; TAS:Reactome; .
GOGO:0051225; P:spindle assembly; IMP:UniProtKB; .
GOGO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome; .
GOGO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW
GOGO:0006412; P:translation; NAS:UniProtKB; .
GOGO:0006413; P:translational initiation; NAS:UniProtKB; .
GOGO:0019083; P:viral transcription; TAS:Reactome; .
Gene3D3.30.1140.32; -; 1; .
Gene3D3.30.300.20; -; 1; .
InterProIPR015946; KH_dom-like_a/b; .
InterProIPR004044; KH_dom_type_2; .
InterProIPR009019; KH_prok-type; .
InterProIPR001351; Ribosomal_S3_C; .
InterProIPR018280; Ribosomal_S3_CS; .
InterProIPR005703; Ribosomal_S3_euk/arc; .
PfamPF07650; KH_2; 1; .
SUPFAMSSF54814; SSF54814; 1; .
SUPFAMSSF54821; SSF54821; 1; .
TIGRFAMsTIGR01008; uS3_euk_arch; 1; .
PROSITEPS50823; KH_TYPE_2; 1; .

USC-OGP 2-DE database image

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Database constructed and maintained by Angel Garcia, using the Make2D-DB II package (ver. 3.10.2) from the World-2DPAGE Constellation of the ExPASy web server